Examples of sedating antihistamines dating america online site
PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE.BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER.[ Read the disclaimer | Adults: Allergic rhinitis, seasonal/perennial: 5 mg po qd. In patients with liver or renal impairment, a starting dose of one 5 mg tablet every other day is recommended based on pharmacokinetic data.Mechanism of Action Desloratadine is a long-acting tricyclic histamine antagonist with selective H1-receptor histamine antagonist activity.A comprehensive review with 185 references for the analysis of commonly prescribed members of an important class of drugs, non-sedating antihistamines (NSAs), is presented.
Histamine affects nearby nerves resulting in itching.
The receptors on which histamine acts are classified as H1, H2, H3 and H4. They are present in the brain, the nervous system, the skin, the stomach, the intestines and so forth.
The action of histamine upon the particular receptors depends on where the histamine is released in the body during the reaction.
Results of a radiolabeled tissue distribution study in rats and a radioligand H1-receptor binding study in guinea pigs showed that desloratadine did not readily cross the blood brain barrier. Dosing: Oral: Children: 6-11 months: 1 mg once daily 12 months to 5 years: 1.25 mg once daily 6-11 years: 2.5 mg once daily Children /= 12 years and Adults: 5 mg once daily Supplied Syrup (Clarinex®): 0.5 mg/m L (480 m L) [bubble gum flavor] Tablet (Clarinex®): 5 mg Tablet, orally-disintegrating (Clarinex® Redi Tabs®): 5 mg [contains phenylalanine 1.75 mg/tablet] Adult (usual) Chronic idiopathic urticaria: 60 mg orally twice daily.
Seasonal allergic rhinitis: 60 mg orally twice daily or 180 mg once daily.
Histamine is the main chemical that is responsible for the allergy reaction and the ensuing symptoms.